目的: 报道1例临床和影像学表现典型额颞叶痴呆病例。方法: 对1例行为变异型额颞叶痴呆患者的临床和神经影像学表现进行分析。结果: 本病例患者表现为社交行为异常,无相关疾病家族史。副肿瘤综合征及自身免疫性脑炎相关抗体阴性。头颅MRI显示双侧额颞叶及海马萎缩,右侧明显。头颅18F-FDG PET显示扣带回、双侧额颞叶FDG摄取明显减低。结论: 神经影像学能反映FTD的病理学改变特征,提高对FTD及其亚型的诊断效能,在FTD诊断、治疗和随访等方面发挥重要作用。
Objective: To report a case of frontotemporal dementia with typical clinical and neuroimaging findings. Methods: The clinical and neuroimaging findings of the reported case were analyzed. Results: The patient presented with bizarre social behavior without family history of related diseases. Antibodies related to paraneoplastic syndrome and autoimmune encephalitis were negative. Brain MRI showed atrophy of bilateral frontotemporal lobes and hippocampus with right predominance. 18F-FDG PET showed marked reduced FDG uptake in cingulate cortex and bilateral frontotemporal lobes. Conclusion: Neuroimaging can visualize the pathological changes of FTD, improve the diagnostic accuracy of FTD and its subtypes, and play an important role in the diagnosis, treatment and follow-up of FTD.
图1 头颅MRI T1WI(A轴位,B冠状位)显示双侧额颞叶及海马萎缩,右侧萎缩更明显。Fig.1 Axial (A) and coronal (B) brain MRI T1WI images show atrophy of bilateral frontotemporal lobes and hippocampus with right predominance. |
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